Research

Overall aim : Chemical exposures and their health effects

We focus on exposomics and metabolomics datasets in neurology, pregnancy, children's health, cancer and diabetes fields. We study how chemical exposures affect biological pathways in the human body and how those pathways can be linked with adverse phenotypes. We focus on chemical agents that have received high and medium priority by the National and International governmental and research organizations.

IDSL has three major Technology aims

1) To develop, integrate and implement software for advancing metabolomics data processing and analysis.

This workflow can be applied on any scale of data generated using a GCMS or LCMS techniques ( low and high both resolutions). See - https://www.nature.com/articles/sdata2018263 and https://www.mdpi.com/2218-1989/9/5/101

2) To develop tools for mapping, visualizing and interpreting dys-regulated metabolic networks in different biological contexts.

Using biochemical and chemical relationships among chemicals, we map metabolic networks which can be used for identifying dys-regulated metabolic pathways and modules. See -

  1. https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-13-99 ,

  2. https://www.nature.com/articles/s41598-017-15231-w ,

  3. https://pubs.acs.org/doi/abs/10.1021/acs.chemrestox.6b00187 ,

  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570467/

  5. https://www.sciencedirect.com/science/article/abs/pii/S0958166917302574

3) To prioritize chemicals using biomedical text mining and database fusion.

We mine PubMed abstracts and PMC full-text data with text mining methods and combine several chemical databases to prioritize chemicals for exposome contexts. See - https://ehp.niehs.nih.gov/doi/full/10.1289/EHP186 and https://ehp.niehs.nih.gov/doi/full/10.1289/EHP4713